![]() ![]() This final statement has caused some consternation and remains controversial. There are, however, insufficient data to support or exclude ipecac administration soon after ingestion of some specific poisons in rare situations." from the Abstract: (). There is not sufficient evidence to warrant any change in the previous Ipecac position papers. Ipecac may delay the administration or reduce the effectiveness of activated charcoal, oral antidotes, and whole bowel irrigation. The routine administration of ipecac at the site of ingestion or in the emergency department should be avoided. Furthermore, the availability of ipecac is rapidly diminishing. there remains no convincing evidence from clinical studies that ipecac improves the outcome of poisoned patients. The 2013 position paper update on the use of syrup of ipecac remained guarded: ". Clinicians should not administer ipecac to a patient who has a decreased level or impending loss of consciousness or who has ingested a corrosive substance or hydrocarbon with high aspiration potential." There are insufficient data to support or exclude ipecac administration soon after poison ingestion. There is no evidence from clinical studies that ipecac improves the outcome of poisoned patients, and its routine administration in the emergency department should be abandoned. In experimental studies, the amount of marker removed by ipecac was highly variable and diminished with time. "Syrup of ipecac should not be administered routinely in the management of poisoned patients. In 1997, the American Academy of Clinical Toxicology position statement recommended against the routine use of syrup of ipecac. ![]() Its use often delays more effective decontamination methods. Syrup of ipecac has subsequently been shown to be inferior to activated charcoal in reducing absorption in toxic ingestion. Over time, however, clinical research began to call this practice into question. Ipecac irritates the stomach lining and chemically stimulates the CRTZ (chemoreceptor trigger zone) in the medulla oblongata of the central nervous system to induce near-immediate vomiting. Historically, this was the rationale for its recommendation in the management of orally ingested poisons. ![]()
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